Decarbonization and Transition to the Post-Lignite Era: Analysis for a Sustainable Transition in the Region of Western Macedonia

For many decades, the Region of Western Macedonia has been Greece’s energy hub, contributing significantly to electricity supply and national growth with the exploitation of lignite deposits for power generation. Lignite, though, has been banned from EU energy source policies towards achieving CO2 emissions reduction, with profound implications on the economy of the region. Despite the importance of this energy transition, a combinatorial analysis for the area in the coal phase-out regime is missing. Therefore, a combined analysis is performed here, and more specifically, a strengths, weaknesses, opportunities, and threats (SWOT) analysis in all the affected sectors, in combination with the examination of the degree of satisfaction with the EU’s energy priorities. The results of the study show that the Region of Western Macedonia has profound strengths and offers many new opportunities during its transition to a new production model. On the other hand, it has high unemployment rates and low rates of competitiveness and innovation. The main threat is the Region’s desertification due to the inability to find sufficient jobs. Considering the Energy Union’s priorities, the Region of Western Macedonia satisfactorily follows the priorities of Europe in its transition to the new production model, with plenty of room for improvement. The analysis performed allows for a just transition strategic planning to minimize social, economic and energy challenges while maximizing sustainable power generation and has implications for all relevant stakeholders, contributing to the implementation of Energy Union governance and climate actions.

Combinatorial analysis reveals highly coordinated early-stage immune reactions that predict later antiviral immunity in mild COVID-19 patients.

While immunopathology has been widely studied in patients with severe COVID-19, immune responses in non-hospitalized patients have remained largely elusive. We systematically analyze 484 peripheral cellular or soluble immune features in a longitudinal cohort of 63 mild and 15 hospitalized patients versus 14 asymptomatic and 26 household controls. We observe a transient increase of IP10/CXCL10 and interferon-ß levels, coordinated responses of dominant SARS-CoV-2-specific CD4 and fewer CD8 T cells, and various antigen-presenting and antibody-secreting cells in mild patients within 3 days of PCR diagnosis. The frequency of key innate immune cells and their functional marker expression are impaired in hospitalized patients at day 1 of inclusion. T cell and dendritic cell responses at day 1 are highly predictive for SARS-CoV-2-specific antibody responses after 3 weeks in mild but not hospitalized patients. Our systematic analysis reveals a combinatorial picture and trajectory of various arms of the highly coordinated early-stage immune responses in mild COVID-19 patients.

EXPLORING QUANTUM COMPUTING POTENTIALS IN SOLVING A COMBINATORIAL OPTIMIZATION PROBLEM TO MINIMIZE EXPOSURE TO COVID-19 DURING A CITY JOURNEY

COVID-19 is an airborne virus that can be spread directly or indirectly from one person to another. Spreading the virus strongly depends on the location and time and hence, a Spatio-temporal event. Moreover, traffic congestion will increase the spread of the virus not only because of the vicinity but also because of increased temperature and humidity in these spaces for a short or long time. This paper introduces a vehicle routing optimization model to reduce COVID-19 exposure risk during a city journey by solving it as a quadratic unconstrained binary optimization problem on a quantum annealing computer. Indeed, the objective of the COVID-19 prevention optimization problem is to minimize the risk of exposure for a given set of road users between origins and destinations. Microsoft Taxi data from the city of Beijing have been used to simulate road users’ movement. The problem has been run onto three different solvers. One of the solvers is executed on classical computers, and two other solvers are executed on hybrid quantum solvers. Hybrid solvers return the solution within less than 0.03 seconds on quantum processing unit time. However, the results will be returned at least 5 seconds after the execution in the classical solver. It is worth mentioning that, as there is no direct access to the quantum computers, it is hard to compare the results on the same scale as the queries will go on a queue in D-wave quantum computers. Applying the proposed model on the trajectory data shows a better distribution of the vehicles on the road network.

Window-Based Multi-Objective Optimization for Dynamic Patient Scheduling with Problem-Specific Operators

The problem of patient admission scheduling (PAS) is a nondeterministic polynomial time (NP)-hard combinatorial optimization problem with numerous constraints. Researchers have divided the constraints of this problem into hard (i.e., feasible solution) and soft constraints (i.e., quality solution). The majority of research has dealt with PAS using integer linear programming (ILP) and single objective meta-heuristic searching-based approaches. ILP-based approaches carry high computational demand and the risk of non-feasibility for a large dataset. In a single objective optimization, there is a risk of local minima due to the non-convexity of the problem. In this article, we present the first pareto front-based optimization for PAS using set of meta-heuristic approaches. We selected four multi-objective optimization methods. Problem-specific operators were developed for each of them. Next, we compared them with single objective optimization approaches, namely, simulated annealing and particle swarm optimization. In addition, this article also deals with the dynamical aspect of this problem by comparing historical window-based decomposition with day decomposition, as has previously been proposed in the literature. An evaluation of the models proposed in the article and comparison with traditional models reveals the superiority of our proposed multi-objective optimization with window incorporation in terms of optimality.

Combinatorial Analysis of Phenotypic and Clinical Risk Factors Associated With Hospitalized COVID-19 Patients.

Characterization of the risk factors associated with variability in the clinical outcomes of COVID-19 is important. Our previous study using genomic data identified a potential role of calcium and lipid homeostasis in severe COVID-19. This study aimed to identify similar combinations of features (disease signatures) associated with severe disease in a separate patient population with purely clinical and phenotypic data. The PrecisionLife combinatorial analytics platform was used to analyze features derived from de-identified health records in the UnitedHealth Group COVID-19 Data Suite. The platform identified and analyzed 836 disease signatures in two cohorts associated with an increased risk of COVID-19 hospitalization. Cohort 1 was formed of cases hospitalized with COVID-19 and a set of controls who developed mild symptoms. Cohort 2 included Cohort 1 individuals for whom additional laboratory test data was available. We found several disease signatures where lower levels of lipids were found co-occurring with lower levels of serum calcium and leukocytes. Many of the low lipid signatures were independent of statin use and 50% of cases with hypocalcemia signatures were reported with vitamin D deficiency. These signatures may be attributed to similar mechanisms linking calcium and lipid signaling where changes in cellular lipid levels during inflammation and infection affect calcium signaling in host cells. This study and our previous genomics analysis demonstrate that combinatorial analysis can identify disease signatures associated with the risk of developing severe COVID-19 separately from genomic or clinical data in different populations. Both studies suggest associations between calcium and lipid signaling in severe COVID-19.